José Lorenzo Alonso Gómez

 

Postdoctoral Fellow

Location:

HCI G-306

Phone:

+41-44-632 2912

e-mail:

José Lorenzo Alonso Gómez

Education

1996-2001:

Study of chemistry at Vigo, Spain.

2001:

Exchange at Szczecin University of Technology.

2001-2002:

MS degree with Prof. Ma Magdalena Cid Fernández at University of Vigo, Spain.

2002-2006:

Ph. D, with Prof. Ma Magdalena Cid Fernández at University of Vigo, Spain.

2003 and 2005:

Exchange with Prof. F. Diederich at ETH Zurich.

2006-present:

Postdoctoral fellow with Prof. F. Diederich

Resorcin[4]arene Cavitands


Cavitands built up of a resorcin[4]arene with different flaps have been developed. Generally these molecules exist in two different geometries: kite (open) and vase (close) wich at the same time can dimerize to capsules by intramolecular interactions (the figure shows as example the equilibrium between capsule and vase conformation of pirrolo cavitands from J. Rebek). In some cases a reversible switching between the two conformations was found by tuning temperature or pH between others. However those environments were far from the physiological ones.

The target of this project then is the synthesis and study of new cavitands also based in the resorcinarene but with different flaps which could experiment vase-kite switching under soft environments.

Publications

C. Sicre, J.-L. Alonso-Gómez, M. M. Cid, Tetrahedron 2006, 62, 11063-11072. Regioselectivity in alkenyl(aryl)-heteroaryl Suzuki cross-coupling reactions of 2,4-dibromopyridine. A synthetic and mechanistic study.

S. Odermatt, J.-L. Alonso-Gómez, P. Seiler, M. M. Cid, F. Diederich Angew. Chem. Int. Ed. 2005, 40, 5074-5078. Shape-persistent chiral alleno-acetylenic macrocycles and cyclophanes by acetylenic scaffolding with 1,3-diethynylallenes.

J.-L. Alonso-Gómez, Y. Pazos, A. Navarro-Vazquez, J. Lugtenburg, M. M. Cid Org. Lett. 2005, 7, 3773-3776. Preparation of C-13(4)-6-methyl anthranilic ester via a Diels-Alder-type process. An experimental and theoretical study to characterize an unexpected isotope exchange.

Last update: Feb. 2007