Valentina Aureggi

 

Postdoctoral Fellow

Location:

HCI G-312

Phone:

+41-44-633 4169

e-mail:

Valentina Aureggi

Education

1996-1999:

Study of Dye Chemistry at the Insubria University, Italy

1999-2003:

Study of Chemistry at the Insubria University, Italy

2001-2002:

Diploma thesis with R. Neier, University of Neuchâtel, Switzerland

2003-2007:

PhD with G. Sedelmeier, Novartis AG, Basel and R. Neier, University of Neuchâtel, Switzerland. Thesis: "Click Chemistry for a New Synthesis of 5-Substituted Tetrazoles and Applications in Organocatalysis"

2007-2008:

Postdoctoral fellow with M. Lautens, University of Toronto, Canada

since 2009:

Postdoctoral fellow with F. Diederich, ETH Zurich

 

Structure-Based Design and Synthesis of Nonpeptidic Inhibitors for the Antimalarial Targent Plasmepsins

Malaria, a life-threatening disease caused by Plasmodium parasites, kills each year more than one million people, and more than 500 million clinical cases are annually registred. The increasing prevalence of multi-drug-resistant strains of Plasmodium falciparum, the parasite that causes the deadliest form of malaria, requires the urgent development of new theraupetic agents.
Plasmepsin proteases PMI, II and IV and histo-aspartic protease (HAP) are involved in hemoglobin degradation. As this metabolic process is central to the growth and maturation of the malaria parasite, the four proteases have been proposed as new therapeutic targets. This project aims at the design and synthesis of new nonpeptidic inhibitors for Plasmepsin II (PMII), also active for the the PMI, IV and HAP. Such compounds are expected to overcome the resist of the parasite against existing antimalarials.

Publications

S. G. Newman, V. Aureggi, C. S. Bryan, M. Lautens, Chem. Commun. 2009, in press. Intramolecular Cross-Coupling of gem-Dibromoolefins: A Mild Approach to 2-Bromo Benzofused Heterocycles.

V. Aureggi, M. Davoust, K. Gericke, M. Lautens, Synlett. 2009, 6, 1004-1008. A Convenient Synthesis of Indolo- and Pyrrolobenzazepines via a Threefold Norbornene-Mediated Domino Reaction.

C. Bryan, V. Aureggi, M. Lautens, Org. Synth. 2009, 86, 36-46. 2-(2,2-Dibromoethenyl)-benzenamine.

V. Aureggi, V. Franckevičius, M. O. Kitching, S. V. Ley, D. A. Longbottom, G. Sedelmeier, Org. Synth. 2008, 85, 72-87. Synthesis of (S)-5-Pyrrolidin-2-yl-1H-Tetrazole.

V. Aureggi, G. Sedelmeier, Angew. Chem., Int. Ed. 2007, 46, 8440-8444. 1,3-Dipolar Cycloadditions: Click Chemistry for the Synthesis of 5-Substituted Tetrazoles from Organoaluminum Azides and Nitriles.

V. Aureggi, G. Sedelmeier, Novartis AG, Patent application 2007, WO 2007/009716. Novel Heterocyclic Tetrazole Derivative.

Last update: Aug. 2009