Corinne Baumgartner

 

PhD Student

Location:

HCI G-328

Phone:

+41-44-633 4741

e-mail:

Corinne Baumgartner

Education

1999-2003:

Study of chemistry at ETH Zurich

2003:

Diploma thesis with Prof. F. Diederich at ETH Zurich

since 2004:

PhD with Prof. F. Diederich at ETH Zurich

Project


CDP in the active site of the MECDP-Synthase (crystal structure 1GX1, Kemp et al.)

Isoprenoids are biosynthesized from isopentenyl diphosphate and the isomeric dimethylallyl diphosphate via the mevalonate pathway or a mevalonate-independent pathway that was identified during the last decade. The non-mevalonate pathway is present in many bacteria, some algae and in certain protozoa such as the malaria parasite Plasmodium falciparum and in the plastids of higher plants, but not in mammals and archaea. Therefore, the enzymes of this pathway have been identified as promising drug targets.
The goal of this work is the de novo-Design and Synthesis of new Inhibitors of the enzyme 2 C-Methyl-D-erythritol 2,4-cyclodiphosphat Synthase (MECDP-Synthase). The active site of the enzyme will be analyzed on the basis of the crystal structure with the aid of the program MOLOC, which was developed by Hoffmann-La Roche AG, Basel. Afterwards an appropriate compound with the optimum steric and electronic complementarities will be assigned as the lead structure and has to be synthesized.

Publications

R. Siegrist, C. Baumgartner, P. Seiler, F. Diederich, Helv. Chim. Acta 2005, 88, 2250-2261. Facile synthesis of diastereomerically and optically pure 2-substituted hexahydro-1H-pyrrolizin-3-ones.

Last update: Nov. 2005