Sara Eisler

 

Postdoctoral Fellow

Location:

HCI G-306

Phone:

+41-1-633 4168

e-mail:

Sara Eisler

Education

1993-1998:

B.Sc. in chemistry, University of Alberta, Edmonton, Canada

1999-2003:

Ph.D. in chemistry, University of Alberta, Edmonton, Cadada, with Prof. Rik Tykwinski

2004-present:

NSERC post-doctoral fellow with Prof. F. Diederich

Amphiphilic Dendrimers: Vectors for Gene Delivery

The search for a non-viral gene transfection agent has resulted in the exploitation of a range of structural motifs. For example, cationic lipids and cationic dendrimers have been found to bind, condense and deliver DNA. Despite these findings, synthetic vectors are still much less efficient at DNA delivery than their viral counterparts. Inspired by the success of cationic lipids and dendrimers, a new class of amphiphilic vectors have been designed that consist of a lipophilic and a hydrophilic dendron connected by a rigid tolane core (e.g. 1). These amphiphilic dendrimers have demonstrated their potential as very effective transfection agents. To maximize their efficiency, we are synthesizing a new series of molecules to explore structure-activity relationships. Extended in vitro biological studies using the DNA carriers are being carried out.

Publications

S. Eisler, A. Slepkov, E. Elliott, T. Luu, R. McDonald, F. G. Hegmann, R. R. Tykwinski. J. Am. Chem. Soc. 2005, 127, 2666-2676. Polyynes as a model for carbyne: Synthesis, physical properties and nonlinear optical response.

T. Luu, E. Elliott, A. D. Slepkov, S. Eisler, R. McDonald, F. A. Hegmann, R. R. Tykwinski. Org. Lett. 2005, 7, 51-54. Synthesis, structure, and nonlinear optical properties of diarylpolyynes.

A. D. Slepkov, F. A. Hegmann, S. Eisler, E. Elliott, R. R. Tykwinski, J. Chem. Phys. 2004, 120, 6807-6810. The surprising nonlinear optical properties of conjugated polyyne oligomers.

S. Eisler, N. Chahal, R. McDonald, R. R. Tykwinski, Chem. Eur. J. 2003, 9, 2542-2550. Alkyne migration in alkylidene carbenoid species: A new method of polyyne synthesis.

A. L. K. Shi Shun, E. T. Chernick, S. Eisler, R. R. Tykwinski, J. Org. Chem. 2003, 68, 1339-1347. Synthesis of unsymmetrically substituted 1,3-butadiynes and 1,3,5-hexatriynes via alkylidene carbenoid rearrangements.

E. T. Chernick, S. Eisler, R. R. Tykwinski, Tetrahedron Lett. 2001, 42, 8575-8578. Modification of the Fritsch-Buttenberg-Wiechell rearrangement: A facile route to unsymmetrical butadiynes.

S. Eisler, R. R. Tykwinski, J. Am. Chem. Soc. 2000, 122, 10736-10737. Migrating alkynes in alkylidene carbenoids: An unprecedented route to polyynes.

S. Eisler, R. McDonald, G. R. Loppnow, R. R. Tykwinski, J. Am. Chem. Soc. 2000, 122, 6917-6928. Structural, vibrational, and electronic characteristics of enyne macrocycles as a function of ring strain.

S. Eisler, R. R. Tykwinski, Angew. Chem. Int. Ed. 1999, 38, 1940-1943. Expanded radialenes: Modular synthesis and characterization of cross-conjugated enyne macrocycles.