Felix Fischer


PhD Student


HCI G-312


+41-1-632 2998


Felix Fischer



Study of chemistry at Ruprecht-Karls-University in Heidelberg


Internship at Weizmann Institute Rehovot


Diploma thesis with Prof. R. Gleiter at Ruprecht-Karls-University in Heidelberg

since 2004:

PhD with Prof. F. Diederich at ETH Zürich


In another avenue of molecular recognition research, we investigate the energetics of the newly discovered orthogonal dipolar interactions in synthetic model systems. Thus, we have quantified the C–F...C=O interactions in chemical double mutant cycles using new derivatives of the Wilcox torsional balance.

A "molecular torsion balance"

In a further effort we are developing new model systems allowing the measurement of the interaction energetics of dipoles like carbonyls, nitriles and C(sp2)-F bonds. Together with quantum mechanical calculations these measurements should increase the understanding of multipolar interactions in molecular recognition events in drug targeting as well as in supramolecular synthesis.


A. Hirsch, F. Fischer, F. Diederich, Angew. Chem. 2006, in press, Phosphate Recognition in Structural Biology.

N. Chronakis, T. Brandmuller, C. Kovacs, U. Reuther, W. Donaibauer, F. Hampel, F. Felix, F. Diederich, A. Hirsch, Eur. J. Org. Chem. 2006, 10, 2296-2308. Macrocyclic cyclo[n]malonates - Synthetic aspects and observation of columnar arrangements by X-ray crystallography.

F. Hof, M. Schar, D. M. Scofield, F. Fischer, F. Diederich, S. Sergeyev, Helv. Chim. Acta 2005, 88, 2333-2344. Preparation of Troger base derivatives by cross-coupling methodologies.

Last update: Oct. 2006