Julie Geist

 

PhD Student

Location:

HCI G-320

Phone:

+41-44-633 4167

e-mail:

Julie Geist

Education

2001-2004:

Study of chemistry at the University Louis Pasteur (ULP) Strasbourg

2004-2007:

ECPM engineering degree, major in organic chemistry, Strasbourg, ECPM (European school of chemical engineering for chemistry, polymers and materials)

2006:

Internship at F. Hoffmann-La Roche, Basel

since 2007:

PhD with Prof. F. Diederich at ETH Zürich

Design and synthesis of potential IspF inhibitors


L.E. Kemp, C. S. Bond, W. N. Hunter, Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 6591-6596.

Isoprenoids are biosynthesized from isopentenyl diphosphate and the isomeric dimethylallyl diphosphate via the mevalonate pathway or a mevalonate-independent pathway that was identified during the last decade. The non-mevalonate pathway is present in many bacteria, some algae and in certain protozoa such as the malaria parasite Plasmodium falciparum and in the plastids of higher plants, but not in mammals and archaea. Therefore, the enzymes of this pathway have been identified as promising drug targets.

The goal of this work is the de novo-Design and Synthesis of new Inhibitors of the enzyme 2 C-Methyl-D-erythritol 2,4-cyclodiphosphat Synthase (MECDP-Synthase). The active site of the enzyme will be analyzed on the basis of the crystal structure with the aid of the program MOLOC, which was developed by Hoffmann-La Roche AG, Basel.

Last update: Feb. 2008