Maude Giroud

PhD Student


Location: HCI G-327
Phone: +41-44-63-34742
Email:
Maude giroud

Education

2006–2009: BSc. in Chemistry and Chemical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL).
2008: Summer student at the University of Neuchâtel. Advisor: Prof. Reinhard Neier.
2009: Internship at Novartis, Basel.
2010: Visiting student at the University of Alberta, Canada. Advisor: Prof. John Vederas.
2010–2012: MSc. in Chemistry, ETH Zürich. Advisor: Prof. François Diederich.
2012–2016: Graduate studies with Prof. F. Diederich, ETH Zürich, with industrial placement at F. Hoffmann-La Roche Ltd.

Structure-Based Drug Design and Synthesis of Inhibitors of Rhodesain, A Target to Fight Against Human African Trypanosomiasis

Protein Structure

Structure-based drug design will be performed in order to explore the active site of rhodesain, a papain-like cysteine protease. Rhodesain has been identified to be a potential target to fight against Human African Trypanosomiasis, also known as African sleeping sickness. It is produced by the parasite Trypanosoma brucei rhodesiense, responsible for the most acute form of the disease, which affects several thousands of persons each year in sub-Saharan countries.


Publications

  1. M. Giroud, M. Harder, B. Kuhn, W. Haap, N. Trapp, W. B. Schweizer, T. Schirmeister, F. Diederich, ChemMedChem 2016, 11, 1042–1047. Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Modulating Binding Affinity by Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds.
  2. L. J. Barandun, F. R. Ehrmann, D. Zimmerli, F. Immekus, M. Giroud, C. Grünenfelder, W. B. Schweizer, B. Bernet, M. Betz, A. Heine, G. Klebe, F. Diederich, Chem. Eur. J. 2015, 21, 126–135. Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT); selected as front cover and VIP paper.
  3. C. T. Lohans, Z. Huang, M. J. van Belkum, M. Giroud, C. S. Sit, E. M. Steels, J. Zheng, R. M. Whittal, L. M. McMullen, J. C. Vederas, J. Am. Chem. Soc. 2012, 134 (48), 19540–19543. Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy.


Last update: September 2016