Thomas Gottschalk

 

PhD Student

Location:

HCI G-320

Phone:

+41-44-633 4167

e-mail:

Thomas Gottschalk

Education

1998-2005:

Study of Chemistry and Political Science at Friedrich-Alexander-University (FAU) Erlangen-Nuremberg

2001:

Research Exchange with D. C. Braddock, Imperial College London, UK

2003-2004:

Research Exchange with J. F. Stoddart, University of California, Los Angeles

2004-2005:

Diploma Thesis with R. W. Saalfrank, FAU Erlangen

2005:

Diplom-Chemiker (Univ., mit Auszeichnung), FAU Erlangen

since 2005:

Graduate Student with F. Diederich, ETH Zurich

2006

Zerweck-Prize of the Universitätsbund der FAU Erlangen

Switchable Container Molecules


Reversible switching between an open and a closed conformation is the key property of novel container molecules that are based on the resorcin[4]arene platform. Whereas the closed form binds cycloalkanes with high strength and remarkable selectivity (cyclohexane is much preferred over cyclopentane and cycloheptane), acid-induced switching converts the host to an open form that immediately releases the encapsulated guest. This process is fully reversible: Neutralization of the acid completely and immediately restores the guest-hosting properties of the container molecule.

Publications

T. Gottschalk, P. D. Jarowski, F. Diederich, Tetrahedron (Symposium-in-Print "Synthetic NanoSystems and NanoMachinery" in honour of Sir J. F. Stoddart), in press. Reversibly Controllable Guest Binding in Precisely Defined Cavities: Selectivity, Induced Fit, and Switching in Novel Resorcin[4]arene-Based Container Molecules.

M. Zürcher, T. Gottschalk, S. Meyer, D. Bur, F. Diederich, ChemMedChem 2008, 3, 237-240. Exploring the Flap Pocket of the Antimalarial Target Plasmepsin II: The "55 % Rule" Applied to Enzymes.

T. Gottschalk, B. Jaun, F. Diederich, Angew. Chem. 2007, 119, 264-268; Angew. Chem. Int. Ed. 2007, 46, 260-264. Container Molecules with Portals: Reversibly Switchable Cycloalkane Complexation.

D. C. Braddock, D. M. Badine, T. Gottschalk, A. Matusuno, M. Rodriguez-Lens, Synlett 2003, 3, 345-348. The Cyclopropylmethylsilane Terminated Prins Reaction: Stereoelectronic Controlled Formation of (E)-Skipped Dienes Alcohols and a (Z)-Skipped Diene Modification.

D. C. Braddock, D. M. Badine, T. Gottschalk, Synlett 2001, 12, 1909-1913. Cyclopropylmethylsilane Terminated Prins Reaction: Stereoelectronic Controlled Formation of (E)-Skipped Dienes.

Last update: April 2008