Cornelius I. R. Gropp

PhD Student

Location: HCI G-322
Phone: +41-44-63-34171
Cornelius Gropp


2009–2012: BSc in Chemistry at the University of Heidelberg, Germany (Studienstiftung fellowship)
2011–2012 Exchange year at the École Polytechnique, Palaiseau, France (Erasmus and Studienstiftung fellowship)
2012: Bachelor Thesis with Dr. F. Gagosz and Prof. A.S.K. Hashmi at École Polytechnique
2012–2013 Visiting researcher at The Scripps Research Institute, La Jolla with Prof. P.S. Baran (Abroad scholarship of the Studienstiftung)
2013–2014: MSc in Chemistry, ETH Zürich, Switzerland (Abroad scholarship of the Studienstiftung)
2014: Master Thesis with Prof. F. Diederich, ETH Zürich, Switzerland
2014: Internship at the Novartis Instiute for Biomedical Research, Basel
Since 2014: Graduate Student with Prof. F. Diederich at ETH Zürich, Switzerland

Alleno-Acetylenic Cage (AAC) Receptors: Chiroptical Switching and Chiral Recognition

Aleno-acetylinic Cages

Molecular recognition studies have greatly advanced the understanding of enantioselective recognition processes by natural and artificial hosts, establishing fundamental concepts, such as the three-point interaction model and Fischer’s shape complementarity. Model systems with confined cavities are ideal to investigate in detail individual interactions and molecular conformations of guests entrapped in their inner phase.

The aim of the project is the development of organic cages based on axial chiral alleno-acetylenes. Combining alleno-acetylenes with receptor molecules, such as recorcin[4]arenes allows the design and synthesis of chiral cages with exceptional chiroptical properties and chiral recognition properties.


  1. I. Pochorovski, J. Milić, D. Kolarski, C. Gropp, W. B. Schweizer, F. Diederich J. Am. Chem. Soc. 2014, 136, 3852–3858. Evaluation of Hydrogen Bond Acceptors for Redox-Switchable Resorcin[4]arene Cavitands.
    (2014: Biogen Idec Innovation Award, ETH Zurich; Redox-Switchable Resorcine[4]arene Cavitands: Molecular Grippers.)
  2. C. Gropp, N. Trapp, F. Diederich, Angew. Chem Int. Ed. 2016, 55, 14444–14449. Angew. Chem. 2016, 128, 14659–14664. Alleno-Acetylenic Cage (AAC) Receptors: Chiroptical Switching and Enantioselective Complexation of trans-1,2 Dimethylcyclohexane in a Diaxial Conformation.
  3. C. Gropp, T. Husch, N. Trapp, M. Reiher, F. Diederich, J. Am. Chem. Soc. 2017, 139, 12190–12200. Dispersion and Halogen-Bonding Interactions: Binding of the Axial Conformers of Monohalo- and (±)-trans-1,2-Dihalocyclohexanes in Enantiopure Alleno-Acetylenic Cages.
  4. C. Gropp, B. L. Quigley, F. Diederich, J. Am. Chem. Soc. 2018, 140, 2705–2717. Molecular Recognition with Resorcin[4]arene Cavitands: Switching, Halogen-bonded Capsules, and Enantioselective Complexation.
  5. C. Gropp,* N. Trapp, Chimia 2018, 72, 245–248. Complexation and Structure Elucidation of the Axial Conformers of Mono- and (±)-trans-Disubstituted Cyclohexanes by Enantiopure Alleno-Acetylenic Cage Receptors.

Last update: June 2018