Christoph Hohn

 

PhD Student

Location:

HCI G-322

Phone:

+41-44-632 4515

e-mail:

Christoph Hohn

Education

2004-2010:

Chemistry studies at Georg-August-University of Göttingen.

2007:

Student Exchange with R. M. Ortuño, Universitat Autònoma de Barcelona.

2008-2009:

Internship at Merck KGaA, Darmstadt.

2009-2010:

Diploma Thesis with F. Diederich at Eidgenössische Technische Hochschule Zürich and C. Ducho at Georg-August-University Göttingen.

2010-2011:

Internship at Novartis Institute for Biomedical Research, Boston.

since 2011:

Graduate Student with F. Diederich at the ETH Zürich.

Structure-Based Design and Synthesis of tRNA-Guanine Transglycosylase (TGT) Inhibitors


Figure 1. Binding site of Z. mobilis TGT with a bound substrate preQ1 (PDB code: 1P0E).



Shigellosis is a highly infectious inflammatory disease causing 160 million episodes and 1.1 million fatalities, annually. The tRNA modifying enzyme tRNA-Guanine Transglycosylase (TGT) was shown to be necessary for efficient and selective translation of the transcription factor virF, which plays a significant role in the invasive mechanism of Shigella. Therefore, TGT is a promising and highly interesting target for the development of new drugs against Shigellosis. The aim of this project is the de novo design and synthesis of potential inhibitors against TGT using MOLOC, a molecular modeling program developed by Hoffmann-La Roche in Basel.

Last update: Nov. 2011