Tobias Kümin

 

PhD Student

Location:

HCI G-322

Phone:

+41-44-63-34171

e-mail:

Tobias Kuemin

Education

2008–2012:

Bachelor Study in Chemistry, ETH Zurich.

2012–2013:

Master Study in Chemistry, ETH Zurich.

2013:

Master Thesis with Prof. F. Diederich, ETH Zurich.

since 2014:

Graduate Student with Prof. F. Diederich, ETH Zurich.

 

New Antimalarials: Structure-Based Design and Synthesis of Inhibitors of Serine Hydroxymethyltransferase (SHMT)

Malaria is one of the most devastating infectious diseases and a major global health issue with about 200 million cases and 600’000 deaths in 2012 (numbers according to the World Health Organization). The occurrence of parasite resistances to existing antimalarials leads to an urgent need for novel drugs with novel modes of action. A newly discribed target enzyme of the malaria causing parasite Plasmodium falciparum is the serine hydroxymethyltransferase (SHMT), which plays an essential role in the DNA precursor synthesis by catalyzing a one-carbon-unit transfer. The aim of the project is the design and the synthesis of PfSHMT inhibitors to stop the cell proliferation of P. falciparum and to circumvent the resistance issue to finally eradicate malaria.

Last update: Nov 2014