Levon Movsisyan

Postdoctoral Fellow


Location: HCI G-312
Phone: +41-44-63-22998
Email:
Levon Movsisyan

Education

2005–2011: Diploma Specialist in Pharmacy, Yerevan State Medical University
2011–2014: Doctor of Philosophy, University of Oxford, Prof. Harry Anderson
2014–2015: Postdoctoral Fellow, University of Oxford, Prof. Harry Anderson
Since 2016: Postdoctoral Research Fellow, ETH, Zürich, Prof. François Diederich

Structure-Based De Novo Design of tRNA-Guanine Transglycosylase (TGT) Inhibitors

tRNA-guanine transglycosylase (TGT) enzyme has been identified as a virulence controlling protein in Shigella bacteria. Annually more than a hundred million people are affected from the bacteria, however, there is no specific treatment available against the disease. This project focuses on the de novo development of novel antibacterial agents capable to effectively inhibit the Shigella TGT enzyme.

Protein Structure

Publications

  1. L. D. Movsisyan, M. Franz, A. L. Thompson, R. R. Tykwinski, H. L. Anderson, J. Am. Chem. Soc. 2016, 138, 1366–1376. Polyyne Rotaxanes: Stabilization by Encapsulation.
  2. Franz, J. A. Januszewski, D. Wendinger, C. Neiss, L. D. Movsisyan, F. Hampel, H. L. Anderson, A. Görling, R. R. Tykwinski, Angew. Chem. Int. Ed. 2015, 54, 6645–6649. Cumulene Rotaxanes: Stabilization and Study of [9]Cumulenes
  3. L. D. Movsisyan, G. M. Greetham, M. Towrie. A. L. Thompson, A. W. Parker, H. L. Anderson, J. Am. Chem. Soc. 2014, 136, 17996–18008. Photophysics of Threaded sp1-Carbon Chains: The Polyyne is a Sink for Singlet and Triplet Excitation.
  4. L. D. Movsisyan, D. V. Kondratuk, M. Franz, A. L. Thompson, R. R. Tykwinski, H. L. Anderson, Org. Lett. 2012, 14, 3424–3426. Synthesis of polyyne rotaxanes.


Last update: August 2016