||Diploma Specialist in Pharmacy, Yerevan State Medical University
||Doctor of Philosophy, University of Oxford, Prof. Harry Anderson
||Postdoctoral Fellow, University of Oxford, Prof. Harry Anderson
||Postdoctoral Research Fellow, ETH, Zürich, Prof. François Diederich
Structure-Based De Novo Design of tRNA-Guanine Transglycosylase (TGT) Inhibitors
tRNA-guanine transglycosylase (TGT) enzyme has been identified as a virulence controlling protein in Shigella bacteria. Annually more than a hundred million people are affected from the bacteria, however, there is no specific treatment available against the disease. This project focuses on the de novo development of novel antibacterial agents capable to effectively inhibit the Shigella TGT enzyme.
L. D. Movsisyan, M. Franz, A. L. Thompson, R. R. Tykwinski, H. L. Anderson, J. Am. Chem. Soc. 2016, 138, 1366–1376. Polyyne Rotaxanes: Stabilization by Encapsulation.
Franz, J. A. Januszewski, D. Wendinger, C. Neiss, L. D. Movsisyan, F. Hampel, H. L. Anderson, A. Görling, R. R. Tykwinski, Angew. Chem. Int. Ed. 2015, 54, 6645–6649.
Cumulene Rotaxanes: Stabilization and Study of Cumulenes
L. D. Movsisyan, G. M. Greetham, M. Towrie. A. L. Thompson, A. W. Parker, H. L. Anderson, J. Am. Chem. Soc. 2014, 136, 17996–18008.
Photophysics of Threaded sp1-Carbon Chains: The Polyyne is a Sink for Singlet and Triplet Excitation.
L. D. Movsisyan, D. V. Kondratuk, M. Franz, A. L. Thompson, R. R. Tykwinski, H. L. Anderson, Org. Lett. 2012, 14, 3424–3426.
Synthesis of polyyne rotaxanes.