Elke Persch


PhD Student


HCI G-306




Elke Persch



Study of Chemistry at Ruprecht-Karls-University Heidelberg


Exchange semester at Lund University with Prof. E. Nordlander


Diploma Thesis with Prof. D. Menche at Ruprecht-Karls-University Heidelberg


Diplom-Chemikerin, Ruprecht-Karls-University Heidelberg


Internship at BASF SE, Ludwigshafen

since 2011:

Graduate Student with Prof. F. Diederich, ETH Zurich


Structure-Based Design, Synthesis and Biological Evaluation of Trypanothione Reductase Inhibitors

The flavoenzyme trypanothione reductase (TR) is a key player in the redox metabolism of the causative agents of human African trypanosomiasis, Chagas’ disease, and leishmaniasis and has been identified as promising potential drug target. Our research focuses on the design, synthesis, and biological evaluation of novel, small-molecule TR inhibitors and the analysis of their binding mode to the large active site of TR in a multidimensional approach.


E. Persch, O. Dumele, F. Diederich, Angew. Chem. Int. Ed. 2015, doi: 10.1002/anie.201408487. Molecular Recognition in Chemical and Biological Systems.

E. Persch, S. Bryson, N. Todoroff, C. Eberle, J. Thelemann, N. Dirdjaja, M. Kaiser, M. Weber, H. Derbani, R. Brun, G. Schneider, E. F. Pai, R. L. Krauth-Siegel, F. Diederich, ChemMedChem 2014, 9, 1880–1891. Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase.

E. Persch, T. Basile, S. Bockelmann, M. Huss, H. Wieczorek, T. Carlomagno, D. Menche, Bioorg. Med. Chem. Lett. 2012, 22, 7735–7738. Synthesis and Biological Evaluation of a Water-Soluble Derivative of the Potent V-ATPase Inhibitor Archazolid.

S. Förster, E. Persch, O. Tverskoy, F. Rominger, G. Helmchen, C. Klein, B. Gönen, B. Brügger Eur. J. Org. Chem. 2011, 5, 878–891. Syntheses and Biological Properties of Brefeldin Analogues.

Last update: Feb 2015