Damien Polet


Postdoctoral Researcher


HCI G-314


+41-44-632 2636


Damien Polet



University of Geneva, BSc and MSc in chemistry


Industrial Research Project at Merck-Serono


Graduate student with Prof. A. Alexakis, University of Geneva


Post-Doctoral Fellow with Prof. K.C. Nicolaou, Scripps Research Institute, USA and Biopolis, Singapore

since 2008:

Postdoctoral Fellow with F. Diederich, ETH Zurich

Design and Synthesis of New Kinase Inhibitors

Kinases phosphorylate a number of downstream proteins and are involved in many important biological pathways. Of particular interest is PKB, whose over-expression in ovarian, breast, prostate and pancreatic cancers makes it an attractive molecular target for cancer therapy. We designed a number of potential inhibitors using Moloc© and propose to synthesize them in a modular fashion.


K. Tissot-Croset, D. Polet, A. Alexakis, Angew. Chem. Int. Ed. 2004, 43, 2426-2428. A highly effective phosphoramidite ligand for asymmetric allylic substitution.

D. Polet, C. Benhaim, S. Rosset, A. Alexakis, Tetrahedron: Asymmetry 2004, 15, 2199-2203. Biphenol-based ligands for Cu-catalyzed asymmetric conjugate addition.

D. Polet, C. Benhaim, S. Rosset, S.March, A. Alexakis, J. Org. Chem. 2004, 69, 5660-5667. Biphenol-Based Phosphoramidite Ligands for the Enantioselective Copper-Catalyzed Conjugate Addition of Diethylzinc.

A. Alexakis, D. Polet, Org. Lett. 2004, 6, 3529-3532. Very Efficient Phosphoramidite Ligand for Asymmetric Iridium-Catalyzed Allylic Alkylation.

K. Tissot-Croset, D. Polet, S. Gille, C. Hawner, A. Alexakis, Synthesis 2004, 2586-2590. Synthesis and use of a phosphoramidite ligand for the copper-catalyzed enantioselective allylic substitution. Tandem allylic substitution-ring closing metathesis.

D. Polet, A. Alexakis, Tetrahedron Lett. 2005, 46, 1529-1532. Cu-catalyzed asymmetric 1,4-addition of Me3Al to nitroalkenes. Synthesis of (+)-Ibuprofen.

D. Polet, A. Alexakis, Org. Lett. 2005, 7, 1621-1624. Kinetic study of various phosphoramidite ligands in the iridium-catalyzed allylic substitution.

A. Alexakis, D. Polet, C. Bournaud, M. Bonin, L. Micouin, Tetrahedron: Asymmetry 2005, 16, 3672-3675. Phophoramidite ligands for the enantioselective iridium-catalyzed asymmetric hydroboration of meso-bicyclic hydrazines.

D. Polet, A. Alexakis, K. Tissot-Croset, C. Corminboeuf, K. Ditrich, Chem. Eur. J. 2006, 12, 3596-3609. Phosphoramidite Ligands in Iridium-Catalyzed Allylic Substitution.

A. Alexakis, C. Malan, L. Lea, K. Tissot-Croset, D. Polet, C. Falciola, Chimia 2006, 60, 124-130. The Copper-Catalyzed Allylic Substitution.

A. Alexakis, S. El Hajjaji, D. Polet, X. Rathgeb, Org. Lett. 2007, 9, 3393-3395. Iridium-Catalyzed Asymmetric Allylic Substitution with Aryl Zinc Reagents.

D. Polet, A. Alexakis, Chemistry Today 2007, 25(Suppl.), 31-32. Asymmetric allylic alkylation catalysed by iridium.

K.C. Nicolaou, Y.-P. Sun, X. S. Peng, D. Polet, D.Y.-K. Chen, Angew. Chem. Int. Ed. 2008, in press. Total synthesis of (+)-Cortistatin.

Last update: Aug. 2008