Laura Salonen

 

PhD Student

Location:

HCI G-320

Phone:

+41-44-632 2955

e-mail:

Laura Salonen

Education

1999-2006:

Study of chemistry at University of Turku, Finland

2002:

Exchange semester at University of Rostock

2004-2005:

Diploma thesis at Merck KGaA, Darmstadt

2006:

Internship at Hoffmann-La Roche AG, Basel

since 2006:

PhD with Prof. F. Diederich at ETH Zurich

Cation-π Interactions at Enzyme Binding Sites

Thromboembolism is a major health concern throughout the world. Thrombotic disorders are due to imbalances in the blood coagulation cascade. Current therapies include various types of heparin, semi- or unselective thrombin and factor Xa inhibitors, and warfarin, which inhibits the synthesis of the coagulation cascade enzymes by inhibiting reduction of vitamin K. Disadvantages for these therapies include bleeding and delayed effectiveness. Thus, finding orally active antithrombotic agents with few side effects is of great importance.

A highly active factor Xa inhibitor by the Diederich group.  K. Schärer, M. Morgenthaler, R. Paulini, U. Obst-Sander, D. W. Banner, D. Schlatter, J. Benz, M. Stihle, F. Diederich, Angew. Chem. 2005, 117, 4474-4479.

The aim of this project is the design and synthesis of novel and efficacious inhibitors and the investigation of their binding interactions.

Last update: Jan. 2007