X–ray Crystal structure (PDB code: 1Q2S) of Z. mobilis TGT bound to a RNA substrate. W. Xie, X. Liu, R. Huang, Nature Struct. Biol. 2003, 10, 781–788.
Shigellosis is a severe inflammatory bowel disease, mainly occurring in developing countries and leading to the death of more than one million people per year. It was shown, that the tRNA post-transcriptional modifying enzyme tRNA–guanine transglycosylase is involved in the virulence of Shigella. Therefore, TGT is a highly attractive target for the treatment of this dysentery disease. Thus, the aim of this project is the design and synthesis of novel inhibitors of TGT.
Last update: May 2013