Andri Schütz

 

PhD Student

Location:

HCI G-314

Phone:

+41 44 632 44 74

e-mail:

Education

2001-2006:

Study of chemistry at ETH Zurich

2006:

Diploma thesis with Prof. F. Diederich at ETH Zurich

since 2006:

PhD with Prof. F. Diederich at ETH Zurich

Structure-based design and synthesis of a potential antimalarial inhibitors, herbicide or remedy against tuberculosis


Anopheles mosquito, the insect vector transmitting malaria.
Picture: Center of disease control and prevention, Atlanta, USA.

Malaria causes a 300 million infections a year, which of 1 million people die. The "third world’s" disease still constitutes one major problem: an increasing resistancy of the parasite against existing drugs could be observerd. Thus, there is a requirement for novel and cheap antimalarials.


Adapted from Nature 2002, 415, 686-693.

This project aims to design, optimize and synthesize lead compounds for the future development into an antimalarial or herbicid using the program MOLOC, developed by Hoffmann-La Roche. The focus is primarily onto enzymes of the DXP pathway.

Publications

F. Hof, A. Schütz, C. Fäh, S. Meyer, D. Bur, J. Liu, D. E. Goldberg, F. Diederich, Angew. Chem. Int. Ed. 2006, 45, 2138-2141. Starving the Malaria Parasite: A New Class of Inhibitors Active Against the Aspartic Proteases Plasmepsins I, II, and IV.

Last update: November 2007