Michael Seet

 

PhD Student

Location:

HCI G-322

Phone:

+41-44-632 45 15

e-mail:

Michael Seet

Education

2003-2008:

Study of chemistry at Philipps-Universität Marburg

2006-2007:

Exchange semester at ETH Zürich with Prof. F. Diederich

2008:

Diploma thesis with Prof. G. Klebe at Philipps-Universität Marburg

2008-2009:

Internship at BASF SE, Ludwigshafen

since 2009:

Graduate student with Prof. F. Diederich, ETH Zürich

Design and Synthesis of Potential Inhibitors of IspD


IspD (4-Diphosphocytidyl-2C-methyl-D-erythritol Synthase, EC 2.7.7.60) is an enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. This pathway occurs in many bacteria, some algae and plants, and in certain protozoa such as the malaria parasite Plasmodium, but is absent in humans. Thus, these enzymes are interesting drug targets for antimalarials, antibiotics or herbicides. The aim of this project is to develop, synthesize and test new potential inhibitors of IspD.

Publications

A. K. H. Hirsch, M. S. Alphey, S. Lauw, M. Seet, L. Barandun, W. Eisenreich, F. Rohdich, W. N. Hunter, A. Bacher, F. Diederich, Org. Biomol. Chem. 2008, 6, 2719–2730. Inhibitors of the Kinase IspE: Structure-activity Relationships and Co-crystal Structure Analysis.

M. C. Witschel, H. W. Höffken, M. Seet, L. Parra, T. Mietzner, F. Thater, R. Niggeweg, F. Röhl, B. Illarionov, F. Rohdich, J. Kaiser, M. Fischer, A. Bacher, F. Diederich, Angew. Chem. Int. Ed. 2011, 50, 7931–7935. Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding.

Last update: February 2012