Michael Seet


PhD Student


HCI G-322


+41-44-632 45 15


Michael Seet



Study of chemistry at Philipps-Universität Marburg


Exchange semester at ETH Zürich with Prof. F. Diederich


Diploma thesis with Prof. G. Klebe at Philipps-Universität Marburg


Internship at BASF SE, Ludwigshafen

since 2009:

Graduate student with Prof. F. Diederich, ETH Zürich

Design and Synthesis of Potential Inhibitors of IspD

IspD (4-Diphosphocytidyl-2C-methyl-D-erythritol Synthase, EC is an enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. This pathway occurs in many bacteria, some algae and plants, and in certain protozoa such as the malaria parasite Plasmodium, but is absent in humans. Thus, these enzymes are interesting drug targets for antimalarials, antibiotics or herbicides. The aim of this project is to develop, synthesize and test new potential inhibitors of IspD.


A. K. H. Hirsch, M. S. Alphey, S. Lauw, M. Seet, L. Barandun, W. Eisenreich, F. Rohdich, W. N. Hunter, A. Bacher, F. Diederich, Org. Biomol. Chem. 2008, 6, 2719–2730. Inhibitors of the Kinase IspE: Structure-activity Relationships and Co-crystal Structure Analysis.

M. C. Witschel, H. W. Höffken, M. Seet, L. Parra, T. Mietzner, F. Thater, R. Niggeweg, F. Röhl, B. Illarionov, F. Rohdich, J. Kaiser, M. Fischer, A. Bacher, F. Diederich, Angew. Chem. Int. Ed. 2011, 50, 7931–7935. Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding.

Last update: February 2012