Laura Shirtcliff


Postdoctoral Fellow


HCI G-328


+41 44 633 4181


Laura Shirtcliff



B.Sc. in Biochemistry and Molecular Biology, UC Santa Cruz, Santa Cruz, CA USA


Research Assistant with Prof. B. Singaram at UCSC


PhD in Organic Chemistry at the University of Oregon, Eugene, Oregon, USA with Prof. M. M. Haley
Thesis: ‘Coarctate’ Cyclizations: Applications to Heterocycle Synthesis

since 2006:

NSF IRFP Postdoctoral Fellow with Prof. F. Diederich

Switchable Nanotubes Based on Resorcin[4]arene Scaffolds

Resorcin[4]arene cavitands having integrated quinoxaline wall flaps undergo marked rearrangements between an extended kite and a contracted vase form depending upon both temperature or pH. The current objective is to incorporate additional switchable components into the cavitands so as to facilitate clear geometric inter-conversions that are reversible and repeatable when exposed to the appropriate stimuli i.e., change in pH or temperature or exposure to different wavelengths of light. These novel dynamic responsive receptors/switches will be investigated for their shape-dependant host-guest complexation behavior, for guest sensing with the capability of optical readout, and for their potential as new read-write memory devices.


L. D. Shirtcliff, R. Herges, M. M. Haley, J. Org. Chem., submitted. Cu- and Rh-Induced Migrations of Isoindazoylyl Carbene/Carbenoids.

E. L. Spitler, L. D. Shirtcliff, M. M. Haley, J. Org. Chem. 2006, 71, in press. Systematic Structure-Property Investigations and Ion Sensing Studies of Pyridine-Derivatized Donor/Acceptor Tetrakis(arylethynyl)benzenes.

L. D. Shirtcliff, J. Rivers, M. M. Haley, J. Org. Chem. 2006, 71, 6619-6622. Synthesis of 2H-indazoles via Lewis acid promoted cyclization of 2-(phenylazo)benzonitriles.

L. D. Shirtcliff, A. G. Hayes, M. M. Haley, F. Koehler, K. Hess, R. Herges, J. Am. Chem. Soc. 2006, 128, 9711-9721. Biscyclization Reactions in Butadiyne- and Ethyne-Linked Triazenes and Diazenes: Concerted versus Stepwise Coarctate Cyclizations.

A. D. Slepkov, J. A. Marsden, J. J. Miller, L. D. Shirtcliff, M. M. Haley, K. Kamada, R. R. Tykwinski, F. A. Hegmann, SPIE 2005, 5934, 593405/1-593405/9. The effects of donor-acceptor substitution symmetry on the nonlinear absorption of two-dimensionally-conjugated isomeric chromophores.

J. A. Marsden, J. J. Miller, L. D. Shirtcliff, M. M. Haley, J. Am. Chem. Soc. 2005, 127, 2464-2476. Structure-Property Relationships of Donor/Acceptor-Functionalized Tetrakis(phenylethynyl)benzenes and Bis(dehydrobenzoannuleno)benzenes.

L. D. Shirtcliff, T. J. R. Weakley, M. M. Haley, F. Koehler, R. Herges, J. Org. Chem. 2004, 69, 6979-6985. Experimental and Theoretical Investigation of the Coarctate Cyclization of (2-Ethynylphenyl)phenyldiazenes.

F. Langa, P. de la Cruz, J. L. Delgado, M. M. Haley, L. Shirtcliff, I. Alkorta, J. Elguero, J. Mol. Struct. 2004, 699, 17-21. The structure of p-nitrophenylhydrazones of aldehydes: the case of the p-nitrophenylhydrazone of 2-diethylamino-5-methoxy-2H-indazole-3-carboxaldehyde.

Last update: Jan. 2007