Michal Tichý

Postdoctoral Fellow


Location: HCI G-312
Phone: +41-44-63-34169
Email:
Michal Tichý

Education

2004–2007: B.Sc. in clinical and toxicological analysis, Charles University in Prague – Faculty of Science (Dr. Jan Šarek)
2007–2009: M.Sc. in organic chemistry, Charles University in Prague – Faculty of Science (Dr. Jan Šarek)
2009–2015: Ph.D. in organic chemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (Prof. Michal Hocek)
Since 2015: Postdoctoral Research Fellow, ETH Zürich, Switzerland (Prof. François Diederich)

Structure-Based Design and Synthesis of CatL and SHMT Inhibitors

Human cathepsin L (hCatL) is cystein protease known to be upregulated in variety of human cancers and has been considered as a target for cancer treatment. Highly similar cathepsin L-like enzymes rhodesain and falcipain-2 are promising targets for treatment of African sleeping sickness and malaria, respectively. Serine hydroxymethyltransferase (SHMT) is an essential enzyme for Plasmodium falciparum, causative agent of malaria. The aim of the project is to develop potent inhibitors of these enzymes to fight above mentioned diseases.


Publications

  1. A. Bosáková, P. Perlíková, M. Tichý, R. Pohl, M. Hocek, Bioorg. Med. Chem. 2016, 24, 4528–4535. 6-Aryl-4-amino-pyrimido[4,5-b]indole 2′-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study.
  2. M. Tichý, R. Pohl, E. Tloušťová, J. Weber, G. Bahador, Y.-J. Lee, M. Hocek, Bioorg. Med. Chem. 2013, 21, 5362–5372. Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides.
  3. M. Tichý, R. Pohl, H. Y. Xu, Y.-L. Chen, F. Yokokawa, P.-Y. Shi, M. Hocek, Bioorg. Med. Chem. 2012, 20, 6123–6133. Synthesis and Antiviral Activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides.
  4. J. Krasulová, R. Hanus, K. Kutalová, J. Šobotník, D. Silliam-Dusse`s, M. Tichý, I. Valterová, J. Chem. Ecol. 2012, 38, 557–565. Chemistry and Anatomy of the Frontal Gland in Soldiers of the Sand Termite Psammotermes hybostoma.


Last update: September 2016