Anthoni Wouter van Zijl

 

Postdoctoral Fellow

Location:

HCI G-316

Phone:

+41-44-632 2636

e-mail:

Anthoni Wouter van Zijl

Education

2009-present:

Postdoctoral research with Prof. F. Diederich, ETH Zürich

2004-2008:

PhD study with Prof. B. L. Feringa, University of Groningen

2003:

Research internship with Prof. A. C. S. Chan, Hong Kong Polytechnic University

2001-2004:

Undergraduate research with Prof. B. L. Feringa, University of Groningen

1997-2004:

Academic study of chemistry at University of Groningen, The Netherlands

Rational design of inhibitors for IspE

IspE is a crucial enzyme for the malaria parasite. Molecular modelling of the active pocket of the enzyme allowed the rational design of a small library of potential inhibitors. These compounds will be synthesised and tested on their activity. The goal of the research is first and foremost to obtain new leads for drug discovery in the fight against malaria, although it should lead to more knowledge concerning the enzyme and how small molecules bind in the active site, also.

Publications

A. W. van Zijl, W. Szymanski, F. López, A. J. Minnaard, B. L. Feringa, J. Org. Chem. 2008, 73, 6994-7002. Catalytic enantioselective synthesis of vicinal dialkyl arrays.

A. W. van Zijl, A. J. Minnaard, B. L. Feringa, J. Org. Chem. 2008, 73, 5651-5653. Straightforward synthesis of α,β-unsaturated thioesters via ruthenium catalysed olefin cross-metathesis with thioacrylate.

K. Geurts, S. P. Fletcher, A. W. van Zijl, A. J. Minnaard and B. L. Feringa, Pure & Appl. Chem. 2007, 80, 1025-1037. Copper Catalyzed Asymmetric Allylic Substitution Reactions with Organozinc and Grignard Reagents.

A. W. van Zijl, F. Lopez, A. J. Minnaard, B. L. Feringa, J. Org. Chem. 2007, 72, 2558-2563. Synthesis of Optically Active Bifunctional Building Blocks through Enantioselective Copper-Catalyzed Allylic Alkylation Using Grignard Reagents.

F. Lopez, A. W. van Zijl, A. J. Minnaard, B. L. Feringa, Chem. Commun. 2006, 409-411. Highly enantioselective Cu-catalysed allylic substitutions with Grignard reagents.

A. W. van Zijl, L. A. Arnold, A. J. Minnaard, B. L. Feringa, Adv. Synth. Catal. 2004, 346, 413-420. Highly enantioselective copper-catalyzed allylic alkylation with phosphoramidite ligands.

H. Malda, A. W. van Zijl, L. A. Arnold, B. L. Feringa, Org. Lett. 2001, 3, 1169-1171. Enantioselective copper-catalyzed allylic alkylation with dialkylzincs using phosphoramidite ligands.

Last update: Jan. 2009