Martina Zürcher

 

PhD Student

Location:

HCI G-312

Phone:

+41-44-633 4169

e-mail:

Martina Zürcher

Education

2001-2005:

Study of chemistry at ETH Zurich

2002/3:

ERASMUS exchange semester at the University of Cambridge, UK

2005:

Diploma thesis with Prof. F. Diederich at ETH Zurich

since 2006:

PhD with Prof. F. Diederich at ETH Zurich

Synthesis of a potential antimalarial

Anopheles mosquito (http://de.wikipedia.org/wiki/anopheles)

Malaria is the most prolific infectious disease in the world, killing up to 3 million people annually mainly in the tropical and subtropical areas of the world.
Plasmepsin (PM) I, II and IV and histo-aspartic protease (HAP) are involved in hemoglobin degradation. As this metabolic process is central to the growth and maturation of the malaria parasite, the four proteases have been proposed as new therapeutic targets.
This project aims at the synthesis of new nonpeptidic inhibitors for Plasmepsin II, which are also active for Plasmepsin I, IV and HAP. Such compounds are expected to overcome the resistance of the parasite against existing antimalarials.

Last update: Oct. 2006